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The table below provides guidelines for leucovorin calcium dosage based upon serum methotrexate levels.

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Information on methotrexate is available on the snac site and if giving your child injections you will have received detailed instruction from your rheumatology team.

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Methotrexate injection protocols have used 50mg m 2 or 75mg intramuscularly or methotrexate tablet protocols use 25mg and 50mg tablets by mouth to terminate pregnancies in patients that are 9 weeks or less gestation.

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Additionally, it is associated with greater improvement in quality of life compared with methotrexate.

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This is because methotrexate causes your body to get rid of more folate as waste than usual.

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folic acid, vitamin b9, is not effective for methotrexate rescue therapy since folic acid requires dihydrofolate reductase for bioactivation and methotrexate inhibits this enzyme.

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