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Hyperbilirubinemia is often associated with atazanavir and or indinavir therapy but does not reflect liver damage and is related to the inhibition of udp glucuronosyltransferase.

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women receiving hormonal contraceptives and anti-retroviral protease inhibitors pis , such as indinavir, should be instructed to report any breakthrough bleeding or other adverse effects to their prescribers.

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at this dose, concurrent use results in increased indinavir auc 53 and cmin 298 .

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ibuprofen; oxycodone moderate concomitant use of oxycodone with indinavir may increase oxycodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.

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ivacaftor is also an inhibitor of cyp3a and p-glycoprotein p-gp ; indinavir is metabolized by cyp3a and is a substrate of p-gp.

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