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amoxicillin; clarithromycin; omeprazole major use caution when administering high-dose methotrexate to patients receiving proton pump inhibitors ppis ; a temporary withdrawal of the ppi should be considered in some patients receiving high-dose methotrexate.

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prilosec may interact with the following medications certain antibiotics, including ampicillin principen, in unasyn ;anticoagulants such as warfarin coumadin ; atazanavir reyataz ; benzodiazepines such as diazepam valium ; cilostazol pletal ; clopidogrel plavix ; cyclosporine neoral, sandimmune ; digoxin lanoxicaps, lanoxin disulfiram antabuse ; diuretics; iron supplements; ketoconazole nizoral ; methotrexate rheumatrex, trexall , nelfinavir viracept ; phenytoin dilantin ; saquinavir invirase ; tacrolimus prograf ; and voriconazole vfend and other prescription antifungal or anti-yeast medications.

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etodolac major in general, nsaid therapy can decrease the clearance of methotrexate, resulting in elevated and prolonged serum methotrexate levels.

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what a surprise when i heard the nurse describe the tiny needle used to inject methotrexate subcutaneously into the fat layer under the skin .

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methotrexate has serious interactions with at least 49 different drugs.

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