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gefitinib major monitor for an increased incidence of gefitinib-related adverse effects if gefitinib and isoniazid, inh are used concomitantly.

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initial testing was done on 47 cultures with known katg gene sequences 20 with s315t mutations, 20 isoniazid-sensitive isolates wild-type katg , 2 s315n, 2 s315i, 1 s315g, 1 s315t t308t double mutant, and 1 isolate with a katg whole-gene deletion.

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patients were considered to have completed therapy if they filled prescriptions consecutively to correspond to 270 doses of isoniazid within 12 months 7 , 120 doses of rifampin in a 6 month period 7 or 12 doses of isoniazid and rifapentine in a 4 month period 12 .

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vitamin b6 is considered the antidote in this situation and is administered as quickly as possible to combat the side effects of isoniazid toxicity.

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