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When trileptal is administered as a single 300 mg dose, in renally impaired patients creatinine clearance 30 ml min the elimination half-life of mhd is prolonged by 60-90 16 to 19 hours with a two fold increase in auc compared to adults with normal renal function 10 hours .

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trileptal has less risk of drug-to-drug interactions, but can increase the rate of elimination and thereby reduce the effectiveness of some drugs – most notably oral contraceptives and felodipine.

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