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Trial, the incidence of adverse reactions was based on 331 heart transplant patients that received corticosteroids and prograf in combination with sirolimus n 109 , prograf in combination with mmf n 107 or cyclosporine modified in combination with mmf n 115 for 1 year.

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prograf inhibits the expression and or production of several cytokines that include interleukin il -1 beta, il 2, il-3, il-4, il-5, il-6, il-8, il-10, gamma interferon, tumor necrosis factor-alpha, and granulocyte macrophage colony stimulating factor.

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overall, the safety profile of oral prograf in these published studies appeared to be similar to what was reported in the large studies, where prograf was used as primary treatment in liver, kidney and heart transplantation.

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